Healthy Eyes

Our priority is providing improved choices for eye care.

Envisioning Better Health

Driven by innovation and leveraging biomarkers as a strategic focus, we delve into the molecular mechanisms of diseases to:

  • Break through the bottlenecks in ophthalmic drug development from the ground up and advance the application of precision medicine in ophthalmic clinical practice.
  • Establish a globally leading large-scale database of tear biomarkers.
  • Develop a range of products for the detection of tear biomarkers, based on our rapid and precise i-ImmunDx® technology.

Immune regulation in the eye

The ocular surface is regularly exposed to allergens, pathogens, and pollutants, triggering inflammation. A strong immune response is necessary to prevent infection, but excessive inflammation can harm the ocular surface and cornea, leading to opacity and blurred vision. This surface functions as a specialized mucosal immune zone with unique anatomical, physiological, and immunological features that support an immune-tolerant environment critical for maintaining vision and eye health. Key elements of this immune system include the tear film, corneal epithelial cells, immune cells, and various soluble immunoregulatory factors.

Ocular Surface Immune Homeostasis

Under normal conditions, the ocular surface immune system avoids triggering inflammation in response to self-tissues, harmless microbes, or environmental antigens. It remains alert, ready to defend against true threats. When local inflammation or damage occurs, resident immune cells shift from maintaining tissue balance to mounting an active immune response. After the threat is resolved and healing occurs, the system returns to its homeostatic state. However, if this balance is disrupted, it can lead to ocular surface diseases.

The Tear Film and Ocular Surface Health

Under normal conditions, the ocular surface immune system maintains tolerance to self-tissues, commensal microbes, and environmental antigens while staying ready to defend against harmful pathogens. When inflammation or damage occurs, immune cells shift from preserving tissue to launching a protective response. Once the threat is cleared and healing begins, the system returns to its balanced state. Disruption of this homeostasis can lead to ocular surface diseases.

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